Web Reference: My research focused on improving and optimizing the Needleman-Wunsch algorithm, a fundamental method in bioinformatics used for the global alignment of DNA, RNA, and protein sequences. The Needleman–Wunsch algorithm is an algorithm used in bioinformatics to align protein or nucleotide sequences. It was one of the first applications of dynamic programming to compare biological sequences. The algorithm was developed by Saul B. Needleman and Christian D. Wunsch and published in 1970. [1] . Enter one or more queries in the top text box and one or more subject sequences in the lower text box. Then use the BLAST button at the bottom of the page to align your sequences. To get the CDS annotation in the output, use only the NCBI accession or gi number for either the query or subject.
YouTube Excerpt: In this video I will discuss the components of a
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