Web Reference: PCF-funded researcher Dr. Ken Pienta explains how cancer kills people. Using ecology, Dr. Pienta expresses how cancer fits into nature not as an apex predator, but rather an invasive... Feb 1, 2022 · This “cancer swamp” has genetic and epigenetic effects at the local ecosystem level to promote metastasis and at the systemic host level to induce cytokine-mediated lethal syndromes, a major cause of death of cancer patients. Ultimately, the harsh “cancer swamp” selects for highly lethal cancer superclones. Simultaneously, the toxic conditions lead to increased rates of necrosis, extinction of native host cell types, and eventual organ failure.
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