Web Reference: In intramembranous ossification, bone develops directly from sheets of mesenchymal connective tissue. In endochondral ossification, bone develops by replacing hyaline cartilage. 1. The fetal hyaline cartilage model develops. 2. Cartilage calcifies, and a periosteal bone collar forms. 3. The primary ossification center forms in the diaphysis. 4. Secondary ossification centers form in the epiphysis. 5. Bone replaces cartilage except at the epiphyseal plates. By the sixth or seventh week of embryonic life, the actual process of bone development, ossification (osteogenesis), begins. There are two osteogenic pathways—intramembranous ossification and endochondral ossification—but bone is the same regardless of the pathway that produces it.
YouTube Excerpt: Endochondral ossification
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