Web Reference: This tutorial describes the core pair-wise sequence alignment algorithms, consisting of two categories: (1) Global sequence alignments algorithms and (2) Local sequence alignment algorithms. In this tutorial you will begin with classical pairwise sequence alignment methods using the Needleman-Wunsch algorithm, and end with the multiple sequence alignment available through CLUSTAL W. In this module, we will look at aligning nucleotide (DNA) and polypeptide (protein) sequences using both global (Needleman and Wunsch) and local (Smith and Waterman) alignment methods. When aligning two sequences, the algorithm will identify the optimal relationship between them.
YouTube Excerpt: EMBOSS Water uses the Smith-Waterman algorithm (modified for speed enhancements) to calculate the local alignment of two ...
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