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Web Reference: The most significant side effects of end-stage liver disease are portal hypertension and primary liver cancer (hepatocellular carcinoma). Complications of these two conditions are the leading causes of hospitalization and death in people with cirrhosis and liver failure. Jan 3, 2025 · Liver disease is the ninth most common cause of death in the U.S. (more than 55,000 deaths a year). The disease also hits some ethnic and racial groups harder than others. For example,... Dec 19, 2025 · The signs of liver failure occur in stages, starting with early symptoms such as nausea, vomiting, itchiness, and yellowing of the eyes or skin (jaundice). Those with end-stage liver disease may experience pain, abdominal swelling, easy bleeding or bruising, and cognitive impairment.

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